Ubiquinol Overview

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MPA CardioSolve is a unique cardiovascular formula that contains a bioactive, trademarked form of coenzyme Q10 (Kaneka QH™) - called ubiquinol - that has a large body of evidence demonstrating its many benefits in humans. CoQ10 typically exists in two forms: ubiquinone and ubiquinol, the latter of which is the fully reduced, bioactive version of CoQ10.

Findings thus far show that ubiquinol is crucial for:

  • Supporting cardiovascular and immune function
  • Enhancing blood flow and nitric oxide production
  • Increasing energy/ATP production (especially in the heart and skeletal muscles)
  • Supporting body tissues including epithelial, connective and nervous tissues
  • Improving blood lipid profiles

If you’re trying to manage oxidative stress and support bioenergetic processes, Kaneka QH™ is an ingredient that should be at the top of your list. This article will walk you through how ubiquinol works to support energy production throughout the body, promote blood flow/cardiovascular health, and act as an antioxidant.

How Kaneka QH™ Ubiquinol Works

Kaneka Nutrients released Kaneka Ubiquinol™ in 2007, and it remains the strongest form of CoQ10 available. This trademarked ingredient is made from all-natural bioidentical CoQ10 that is fermented by yeast. Since it comes in bioactive, fulled reduced form, Kaneka Ubiquinol™ will rapidly restore healthy levels of CoQ10 in the body.

In fact, just two weeks of supplementing with 150 mg/day of ubiquinol was shown to increase mean CoQ10 plasma levels nearly 5-fold in healthy adult males.1 MPA CardioSolve contains an above-clinical dose of 200 mg Ubiquinol™ per serving.

With that in mind, here are the major research-backed reasons you should be using Kaneka Ubiquinol.

Bioenergetic and Antioxidant Actions of Ubiquinol

In healthy individuals, ubiquinol is found abundantly in metabolically demanding tissues and organs throughout the body, especially the heart, kidneys, skeletal muscles, liver, and brain. As an integral part of the electron transport chain (which takes place in the inner membrane of mitochondria), ubiquinol assists in the synthesis of adenosine triphosphate (ATP) - the energetic currency of cells. In so doing, CoQ10 converts between ubiquinone and bioactive (fully reduced) ubiquinol while acting as an antioxidant and effectively “trapping” free radicals.

Free radicals are chemical species that contain one or two unpaired electrons, such as the superoxide anion (SO2-). These molecules are exceptionally reactive, meaning they are antsy to reach equilibrium and ‘steal’ an electron from nearby intact molecules. The process of a free radical taking an electron from another molecule is known as oxidation. (Thus, the term oxidative stress).

While some oxidative stress is healthy, excessive oxidative stress is well-known to lead to innumerable health consequences.2 In particular, superfluous oxidative stress can cause uncontrolled inflammation, cancer, hypertension, multiple organ failure, and diabetes. This is why ubiquinol is imperative, especially since research shows that low ubiquinol is associated with higher oxidative stress.3

Moreover, be wary of products that list ubiquinone or simply CoQ10 as an ingredient, as most of that will not be converted to full reduced ubiquinol in your body. (In other words, you’re wasting money by not choosing a product with bioactive ubiquinol.)

Cardiovascular and Blood Flow Support

Research shows that ubiquinol supports proper blood flow throughout the cardiovascular system by preserving the activity of nitric oxide - a molecule that dilates/expands blood vessels and helps promote healthy blood pressure.4 

Even short-term supplementation with 200 mg ubiquinol per day had significant NO-fortifying effects in well-trained athletes.5 Those who took a placebo had a notable decrease in plasma NO after one bout of intense exercise, whereas those who supplemented with ubiquinol preserved almost all of their plasma NO. This suggests that maintaining healthy amounts of ubiquinol will help prolong and potentiate the effects of a vasodilating compounds, like those found in CelluVOL.

CoQ10 Ubiquinol Supplementation

Data suggests that ubiquinol supplementation is of growing importance, particularly in aging individuals who don’t properly convert supplemental ubiquinone to active ubiquinol.6

Given the nature of ubiquinol for supporting overall health and well-being, supplementation with MPA CardioSolve must be considered for those who are aging, on performance-enhancing substances, training vigorously, and/or on a low-calorie diet.

References

  1. Schmelzer, C., Niklowitz, P., Okun, J. G., Haas, D., Menke, T., & Döring, F. (2011). Ubiquinol‐induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans. IUBMB life, 63(1), 42-48.
  2. Finkel, T., & Holbrook, N. J. (2000). Oxidants, oxidative stress and the biology of ageing. Nature, 408(6809), 239.
  3. Yamamoto, Y., & Yamashita, S. (1997). Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress. Molecular aspects of medicine, 18, 79-84.
  4. Moncada, S. R. M. J., Palmer, R. M. L., & Higgs, E. (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacological reviews, 43(2), 109-142.
  5. Sarmiento, A., Diaz‐Castro, J., Pulido‐Moran, M., Moreno‐Fernandez, J., Kajarabille, N., Chirosa, I., ... & Ochoa, J. J. (2016). Short‐term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial. BioFactors, 42(6), 612-622.
  6. Langsjoen, P. H., & Langsjoen, A. M. (2014). Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clinical pharmacology in drug development, 3(1), 13-17.

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