By: Matt Weik

If you’re dedicated to improving your health and physique, you’re probably spending a fair amount of time working out.  Additionally, eating the right foods and supplementing with the right products is probably high on your priority list. 

For many, the next big thing to hit the supplement market excites us, and the thought of being able to see better results from our efforts further increases our motivation level. 

With that being said, there is an ingredient that has been around for quite some time but not many people have heard about or taken much notice of it. The ingredient I’m referring to is Nitrosigine®. 


 A Safe and Effective Patented Ingredient

Nitrosigine is a patented ingredient that is showing up in various pre-workouts. Some of them are loaded with stimulants while some of them are not and focus more on cellular and muscular volumization. 

If you’re a chaser of “the pump” during workouts, you’re going to absolutely fall in love with Nitrosigine. Essentially, Nitrosigine is everything arginine was supposed to be.

Getting a little geeky for those who are interested in what exactly Nitrosigine is, this patented ingredient has a very uniquely bonded complex of arginine and silicon. Inositol is also attached to help provide a 1:1 ratio of arginine and silicon. The bonded complex has been found to possess some synergistic effects1 that can help enhance your training. 


If you have spent any amount of time in the supplement industry and taking supplements, you have probably heard of arginine before. It’s a pump-inducing ingredient that increases nitric oxide levels and aid in vasodilation. But one ingredient you may not be as familiar with is silicon and how it can aid in enhancing your workout.  Silicon is an element that has been shown to help with maintaining the integrity of the lining of the aortic tissues. Silica makes the inner lining of arterial tissue less permeable.

Arginine bound to silicon (arginine silicate) was demonstrated to increase blood flow throughout tissues twice as well as arginine HCl – not to mention, arginine silicate elicits 5x greater blood vessel relaxation than arginine HCl2Nitrosigine is clinically dosed at 1500mg which is where the research has shown the most benefits from its use.

As with many supplements on the market, some people are worried about the safety and risks involved with using supplements – including patented ingredients like Nitrosigine. The good news is, Nitrosigine has been declared as GRAS (generally recognized as safe), as evaluated by the Food and Drug Administration, and is deemed an effective and beneficial ergogenic aid. 


Nitrosigine Has Numerous Benefits Without the Need for Stimulants

Next, let’s get into what you’ve probably been waiting for – the meat and potatoes of Nitrosigine. What exactly can Nitrosigine do for you and what can you experience through its use?

Below are some key benefits of Nitrosigine (in no particular order) to help you better understand what this powerful ingredient is capable of.

1.     Boost Nitric Oxide Levels

One of the biggest reasons people will want to choose a product that utilizes Nitrosigine is its ability to increase nitric oxide (NO) levels and flow in the blood vessels. This, in turn, can help produce intense skin-tightening pumps that can help you look fuller and more muscular for upwards of six hours after use.  In addition, the vasodilation properties can also improve vascularity – creating that roadmap of visual veins that so many desire.


Nitrosigine has been found to be more effective at increasing nitric oxide levels than L-Arginine, Arginine AKG, L-Citrulline, Citrulline Malate, and Agmatine Sulfate. An increase in “the pump” helps allow for muscle growth. 

When there is an increase in nitric oxide and blood flow, it allows both oxygen and key nutrients to enter the muscle as well as aid in the removal of waste products that form from intense bouts of exercise.

2.     Stim-Free Increase in Energy Levels

Are you sensitive to stimulants? If so, Nitrosigine could be exactly what you’re looking for in a pre-workout supplement. Nitrosigine can provide you with a steady boost of energy that compounds with each passing day. 

That means, the longer you use the product, the more significant the increases in energy you can experience over time1. From the very first dose, you can experience how effectively Nitrosigine is at boosting energy levels without all of the common side effects so many experience when using stimulants.


3.     Enhanced Cognitive Function


Mental focus in the gym is extremely important. It’s all about enhancing your mind-muscle connection so you can concentrate on fully contracting and stretching the working muscle with each repetition. 

You want to put your focus on activating only the muscle fibers of the muscle group you are working with so that other muscles do not come into play and assist with the movement – which would remove some of the tension off of the primary working muscles.

A single dose of Nitrosigine has been shown to significantly increase mental acuity by as much as 33% in as short as 15 minutes following consumption1. You can also achieve a compounding effect on mental acuity when Nitrosigine is used regularly. 

4.     Improve Recovery

At the end of the day, recovery is a major limiting factor when it comes to your success and results. You are only as good as your ability to quickly and effectively recover following workouts. With the help of Nitrosigine, you can prep your muscles for the workload ahead while also reducing markers of muscle damage from exercise.


Research has shown that through the use of Nitrosigine, you can reduce creatine kinase levels by as much as 56%1. This can help you recover faster following workouts while also helping you push harder during. In turn, Nitrosigine can help you increase lean muscle growth.

5.     Feel the Effects Within 15 Minutes

On training days, the last thing you want to do is wait for your pre-workout to kick in. With Nitrosigine, you can feel the effects in as short as 15 minutes2 after taking it. In that short amount of time you can start to feel the energy-enhancing properties start setting in, your muscles start feeling fuller, and your focus is getting completely dialed in. 


By the time you hit the weight room, you’re ready to get down to business and put in the work. No wait – just work to be done with the iron.

6.     Effects Last Up to 6 Hours

When you achieve a muscle pump, the last thing you want to see is your fullness disappearing shortly after your workouts. 

With Nitrosigine, it doesn’t have to. In fact, the powerful effects of Nitrosigine can allow you to experience muscle volume and fullness for upwards of six hours3 following your workout. Nitrosigine has been shown to help accomplish this by effectively increasing nitric oxide production and blood arginine levels.

7.     No Crash or Jitters

Because Nitrosigine is not a stimulant, through its use you will not experience any sort of crash or energy dump like you may experience when using a pre-workout that includes stimulants – like with caffeine, for example.


This means no rollercoaster ride of up and down energy levels with a sudden crash post-workout. Additionally, you will not feel any jitters that are also common with many stimulant-based pre-workouts.

8.     No Tolerance from Use

Unlike many supplements out there where you can build up a tolerance, Nitrosigine is not one of them. This will allow you to get the same benefits dose after dose without the need to ramp up how much you need to achieve the desired results.

For instance, have you ever used a pre-workout that was full of stimulants, and after a month or so you notice one scoop just isn't cutting it anymore and you need to increase your dose to two scoops? Then after a while, two isn't enough and you need to jump up to three?  With Nitrosigine, one serving is more than enough and whether it’s your first week using it or 15 months of continuous use, the effects you experience can remain the same.

Fuel Your Workouts and Experience Unreal Muscle Pumps with MPA CelluVOL™

If you want to add quality muscle mass, experience intense muscle-swelling pumps, attain laser-like focus, increase recovery, and energize your workouts so you can maximize your time in the gym, MPA CelluVOL is THE ultimate stim-free pre-workout.

With an efficacious dose of 1500mg worth of Nitrosigine, you’re going to wonder how you’ve ever walked into the gym without it. In addition to using a clinically-researched dose of Nitrosigine, MPA CelluVOL also includes other hard-hitting patented ingredients like HydroMax®AlphaSize®, and ElevATP®. 

MPA pulled out all the stops in producing the industry’s leading stim-free pre-workout – CelluVOL. Try it for yourself and take your workouts to another level!




  1. Rood-Ojalvo S, Sandler D, Veledar E, Komorowski J. The benefits of inositol-stabilized arginine silicate as a workout ingredient. Journal of the International Society of Sports Nutrition. 2015; 12(Suppl 1): P14.
  2. Proctor SD, Vine DF, Russell JC. A novel complex of arginine-silicate improves micro- and macrovascular function and inhibits glomerular sclerosis in insulin-resistant JCR: LA cp rats. Diabetologia 2005; 48:1925-1932.
  3. Komorowski J, Perez Ojalvo S. A pharmacokinetic evaluation of the duration of effect of inositol-stabilized arginine silicate and arginine hydrochloride in healthy adult males. The FASEB Journal. 2016; 30(1) Supplement 690.17.


Author Bio:

Matt Weik, the owner of Weik Fitness, LLC, is a well-respected fitness expert/author with a global following. His work has been featured all over the globe as well as having published numerous books. He is a certified strength and conditioning specialist, personal trainer, and sports nutritionist. Find out more at or on social media @weikfitness.