Ghrelin: An Ectomorph's Solution to Muscular Weight Gain

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The endogenous growth hormone secretagogue Ghrelin may play a paramount role in your quest for muscle growth. This gastric hormone stimulates hunger in mice and in humans by binding to the ghrelin receptors located in the hypothalamus and the hippocampus.

Reasons why people feel the urge to eat

Ghrelin is highest when blood sugar is low and being in a fasted state. Ghrelin is a potent endogenous growth hormone releaser, and is the strongest of the secretagogues. Even though it increases growth hormone release, some of its effects are quite different from growth hormone itself. Ghrelin encourages lipogenesis, whereas growth hormone supports lipolysis. Ghrelin also supports glucose oxidation, while growth hormone suppresses insulin production for inhibited glucose disposal. This equates to ghrelin being highly effective for weight gain through adipogenic  pathways and growth hormone supporting weight loss through lipolytic  pathways.

Ghrelin Effects:                                            Synthetic Growth Hormone Effects:

-Increases endogenous GH                                -Synthetically derived

-Encourages lipogenesis (fat gain)                     -Encourages lipolysis (fat loss)

-Increases glucose oxidation                             -May promote insulin resistance

-Great for weight gain                                       -Great for fat loss

Knowing such facts makes it very clear that ghrelin would be perfect for the ectomorphic, hard gainer body type. If you are someone who frequents the bodybuilding internet forums, then you are probably aware of the recent surge in popularity with research peptide companies. These companies sell a product called GHRP-6, which is a hexapeptide comprised of 28 amino acids that signals the pituitary to secrete growth hormone through increasing ghrelin production. Using GHRP-6 in conjunction with a regimented weight training program and a meticulously planned diet, the ectomorphictrainee could consume copious amounts of high quality nutrients to achieve muscular weight gain that once seemed impossible.

- I must mention - one must be very precautious and assured with whom they decide to research with, meaning make sure the company is of high quality, and the peptides are USA grade ingredients.

References -

1.) Cordido, Fernando; Isidro, Maria L.; Nemina, Rosa; Sangiao-Alvarellos, Susana, Ghrelin and Growth Hormone Secretagogues, Physiological and Pharmacological Aspect. Volume 6, Number 1, March 2009 , pp. 34-42(9)

2.) .Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ, Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.
N Engl J Med. 2002 May 23;346(21):1623-30.

3.) Britt Edén Engström, Pia Burman, Camilla Holdstock and F. Anders Karlsson,
Effects of Growth Hormone (GH) on Ghrelin, Leptin, and Adiponectin in GH-Deficient Patients. The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 11 5193-5198

 

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